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Target intelligence / Profile preview
CD20 Antigen (B Lymphocyte Antigen) (CD20)
- Target
- CD20
- Molecular classification
- Tetraspanin, Transmembrane protein
01
Overview
CD20, also known as B-lymphocyte antigen CD20, is a non-glycosylated transmembrane protein expressed on the surface of B cells. It plays roles in B-cell development, differentiation, signaling, and membrane organization. It serves as a key biomarker and therapeutic target in various B-cell malignancies and autoimmune diseases. Anti-CD20 antibodies, such as rituximab, are used to deplete B cells in these conditions.
- Other names
- B-lymphocyte antigen CD20MS4A1Membrane-spanning 4-domains, subfamily A, member 1
02
Mechanism of action
Anti-CD20 antibodies bind to CD20 on B cells, leading to B-cell depletion through mechanisms such as complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), and apoptosis.
03
Biological functions
B-cell developmentB-cell differentiationB-cell receptor (BCR) signalingCell cycle initiationMembrane organizationCalcium channel regulationImmune response
04
Disease associations
Non-Hodgkin lymphomaChronic lymphocytic leukemiaAutoimmune diseasesB-cell malignancies
05
Safety considerations
Infusion reactionsTumor lysis syndromeProgressive multifocal leukoencephalopathy (PML)Increased risk of infectionsCytopenias
06
Interacting drugs
Rituximab
07
Biomarkers
CD20 expression level (for diagnosis, treatment planning, and patient selection)
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