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Target intelligence / Profile preview
CD20 Molecule (CD20)
- Target
- CD20
- Molecular classification
- Transmembrane protein
01
Overview
CD20 is a non-glycosylated, B lymphocyte cell-surface protein expressed on B cells from the pre-B cell stage through maturity but absent on hematopoietic stem cells, pro-B cells, and terminally differentiated plasma cells. It plays roles in B-cell development, differentiation, and signal transduction. It is a therapeutic target in B-cell malignancies and autoimmune diseases.
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), Direct induction of programmed cell death
03
Biological functions
Regulation of B-cell developmentDifferentiationSignal transduction via the B-cell receptor (BCR)Cell-cycle initiationCalcium signalingMaintenance of resting state in naive B-cells
04
Disease associations
Lymphoproliferative disordersB-cell malignanciesAutoimmune diseases
05
Interacting drugs
Rituximab
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