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Target intelligence / Profile preview
CD200
- Target
- CD200
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily member
01
Overview
CD200 is a cell surface glycoprotein that plays a key immunoregulatory role through its interaction with the inhibitory receptor CD200R. This interaction delivers an inhibitory signal, attenuating immune responses. It is widely expressed on various cell types, including myeloid and lymphoid lineage cells, epithelial cells, endothelial cells, fibroblasts, and neurons, and is also present on many cancer cell types. CD200 is involved in maintaining self-tolerance, preventing excessive inflammation, and regulating tissue homeostasis. Dysregulation of the CD200/CD200R pathway is implicated in autoimmune diseases, chronic inflammation, tumor immunity, and bone homeostasis. Therapeutic strategies are being explored to target this axis for enhancing anti-tumor immunity or reducing pathological inflammation/autoimmunity.
- Other names
- OX2MRC OX-2
02
Mechanism of action
Agonizing CD200R to reduce inflammation/autoimmunity; Blocking CD200/CD200R axis to enhance anti-tumor immunity
03
Biological functions
ImmunoregulationMaintenance of self-tolerancePrevention or attenuation of excessive inflammationModulation toward Th2-type immune responsesRegulation during tissue homeostasisBone mass regulationWound healing
04
Disease associations
Autoimmune diseasesChronic inflammationTumor immunityBone homeostasisAllograft rejection
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