Target intelligence / Profile preview

CD200 Activation Receptor (CD200AR)

Target: CD200AR
Molecular classification: Receptor, Type I transmembrane glycoprotein, Immunoglobulin superfamily

Overview

CD200 activation receptors are a family of activating receptors related to the CD200R family. They are type I transmembrane glycoproteins with Ig-like domains. Unlike the inhibitory CD200R, these receptors do not bind native CD200 effectively but may respond to viral mimics or engineered ligands. Engagement of CD200 activation receptors leads to immune cell activation. These are investigated as potential therapeutic targets in cancer and other immune-related conditions.

Other names: CD200ARsCD200R activating receptorPaired CD200 receptorhP1A8/CD200AR-Ligand target

Mechanism of action

Agonist of CD200 activation receptor; promotes immune cell activation.

Biological functions

Immune responseSignal transductionT cell co-stimulation (potential)Myeloid cell activation (potential)

Disease associations

CancerInflammationAutoimmune disease

Safety considerations

Potential for cytokine stormOff-target effects due to structural similarity to inhibitory CD200RUnpredictable immune responses

Interacting drugs

hP1A8/CD200AR-Ligand (synthetic peptide)

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