CD200 receptor 1 like (CD200R1L)

CD200 receptor 1 like (CD200R1L) is a member of the CD200 receptor family and encodes a cell surface transmembrane glycoprotein receptor structurally related to the inhibitory receptor CD200R1, but functions as an activating receptor mainly on human neutrophils[2][3][4][5]. Unlike CD200R1, which suppresses immune activity, CD200R1L enhances cellular activation, driving immune responses such as reactive oxygen species production via Syk, PI3Kβ, PI3Kδ, and Rac GTPase signaling pathways[2]. The receptor is evolutionarily conserved among vertebrates and is believed to provide rapid immunological responses to pathogens, reflecting a process of convergent evolution in host defense[2]. While it shares high sequence similarity with CD200R1, CD200R1L does not bind the CD200 ligand, highlighting structural adaptation for its activating role[3]. CD200R1L is predicted to be involved in regulation of neuroinflammatory responses as well[5]. No drugs are approved to specifically target CD200R1L and it is not currently in clinical use, but its unique immunostimulatory function makes it a theoretical candidate for modulation in infectious diseases and autoimmunity research.

Other names

CD200 receptor 1 likeCell surface glycoprotein CD200 receptor 2CD200R2CD200 receptor-like 2CD200RLaCD200 cell surface glycoprotein receptor-like 2CD200 cell surface glycoprotein receptor-like aCell surface glycoprotein CD200 receptor 1-likeCell surface glycoprotein OX2 receptor 2HuCD200R2cell surface glycoprotein CD200 receptor 2CD200 cell surface glycoprotein receptor 2CD200 receptor 2cell surface glycoprotein CD200 receptor 1-likecell surface glycoprotein OX2 receptor 2MO2R2

Activation of signaling via Syk, PI3Kβ, PI3Kδ, and Rac GTPase in neutrophils[2]