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Target intelligence / Profile preview
CD22 antigen (CD22)
- Target
- CD22
- Molecular classification
- Type I integral membrane protein, Immunoglobulin superfamily, Receptor
01
Overview
CD22 is a B cell-specific transmembrane glycoprotein that functions as an inhibitory coreceptor on the surface of B lymphocytes. It modulates both innate and adaptive aspects of humoral immunity by setting thresholds for activation signals received via antigen receptors or Toll-like receptors (TLRs). It is an attractive target for therapies against autoimmune diseases or blood cancers involving dysregulated/dysfunctional B-cells.
- Other names
- BL-CAM
02
Mechanism of action
CD22 acts as an inhibitory regulator by attenuating signaling through the B cell receptor (BCR). Therapeutic targeting involves disrupting CD22 function or utilizing it for targeted drug delivery to B cells.
03
Biological functions
B cell receptor signaling modulationInhibitory coreceptor functionRegulation of humoral immunitySignal transductionB cell maturation
04
Disease associations
Autoimmune diseasesB-cell malignanciesHairy cell leukemiaNon-T-cell acute lymphoblastic leukemias
05
Safety considerations
Resistance mechanisms involving loss/modulation/downregulation at tumor surfacesOff-target effects due to CD22 expression on normal B cells
06
Interacting drugs
Monoclonal antibodies targeting CD22
2 more in the full profile.
07
Biomarkers
CD22 expression levels in B cellsSialic acid-containing ligands expression
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