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Target intelligence / Profile preview
CD22 molecule (CD22)
- Target
- CD22
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
CD22 is a B cell-specific transmembrane glycoprotein that functions as an inhibitory co-receptor for the B cell receptor (BCR). It plays a crucial role in regulating immune responses by modulating BCR signaling and maintaining immune tolerance. Its selective expression on B cells makes it a valuable therapeutic target in autoimmune diseases and B cell malignancies.
- Other names
- Siglec-2SIGLEC2
02
Mechanism of action
Monoclonal antibody-drug conjugate targeting CD22, leading to cell death
03
Biological functions
Immune regulationModulation of B cell receptor (BCR) signalingMaintenance of immune toleranceRegulation of TLR signaling
04
Disease associations
Autoimmune diseasesAcute lymphoblastic leukemia (ALL)
05
Safety considerations
Potential for off-target effects due to CD22 expression on normal B cellsImmunogenicity of antibody-based therapies
06
Interacting drugs
Inotuzumab ozogamicin
07
Biomarkers
CD22 expression level for patient selection in ALL
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