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Target intelligence / Profile preview
CD23 Receptor (FcεRII)
- Target
- FcεRII
- Molecular classification
- C-type lectin, Receptor
01
Overview
CD23, also known as Fc epsilon RII (FcεRII), is the low-affinity receptor for immunoglobulin E (IgE). It plays a central role in regulating IgE responses, which are critical in allergy and immune defense against parasites. Unlike most antibody receptors, CD23 is a C-type lectin. It is expressed on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. CD23 has been implicated in allergic diseases due to its regulatory effects on IgE levels, making it a potential therapeutic target for interventions aimed at modulating allergic inflammation or autoimmunity.
- Other names
- Fc epsilon RIICLEC4J
02
Mechanism of action
Modulation of IgE responses, alteration of allergic inflammation
03
Biological functions
Regulation of serum IgE levelsAntigen presentationModulates immune responseImmune response
04
Disease associations
Allergic diseasesAllergy regulation
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