Molecular Classification
Type I transmembrane glycoprotein
Other Names
Endosialin, Tumor Endothelial Marker 1
Disease Roles
CancerFibrosis

CD248 Overview

CD248, also known as endosialin or tumor endothelial marker 1 (TEM1), is a type I transmembrane glycoprotein that plays significant roles in tissue development, tumor biology, and fibrotic diseases. It promotes stromal cell proliferation and migration during tissue remodeling, contributing to angiogenesis by supporting pericyte proliferation around new blood vessels in tumors. On naive human CD8+ T-cells, it appears to inhibit cell proliferation. Diseases linked to aberrant CD248 expression include various cancers and fibrotic disorders. Several experimental therapeutics are being developed against CD248, including monoclonal antibodies, antibody-drug conjugates, CAR-T therapies, and therapeutic vaccines.

Mechanism of Action

Disrupts tumor blood vessel formation/functionality

Biological Functions

Stromal cell proliferation
Stromal cell migration
Angiogenesis support
Maintains quiescence in naive human CD8+ T-cells

Disease Associations

Cancer
Fibrosis

Safety Considerations

  • Limited normal-tissue expression minimizes toxicity

Interacting Drugs

MORAb-004

Associated Biomarkers

Biomarker
Sarcoma progression
Metastatic potential