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Endosialin (None)
- Target
- None
- Molecular classification
- Transmembrane glycoprotein, C-type lectin receptor
01
Overview
Endosialin, also known as Tumor Endothelial Marker 1 (TEM1) or CD248, is a transmembrane glycoprotein highly expressed in the tumor stroma, particularly in cancer-associated fibroblasts and pericytes. It plays a role in promoting tumor progression through enhancing cell adhesion, migration, and proliferation, stimulating angiogenesis, and inducing an immunosuppressive microenvironment. Due to its restricted expression outside tumors, it is considered an attractive target for anti-cancer therapy.
- Other names
- Tumor Endothelial Marker 1TEM1CD248CD164L1
02
Mechanism of action
Antibody-mediated internalization and disruption of vessel function
03
Biological functions
Cell adhesionCell migrationCell proliferationAngiogenesisImmunomodulationExtracellular matrix interaction
04
Disease associations
CancerAtherosclerosis
05
Interacting drugs
MORAb‑004
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