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Target intelligence / Profile preview
CD26 antigen (CD26)
- Target
- CD26
- Molecular classification
- Ectoenzyme, Receptor, Type II transmembrane protein
01
Overview
CD26, also known as dipeptidyl peptidase IV (DPPIV), is a 110 kDa single-chain glycoprotein expressed on the surface of various cell types, most notably immune cells. It functions both as an ectoenzyme with dipeptidyl peptidase IV activity and as a receptor for adenosine deaminase (ADA). It plays a role in immune modulation, T-cell activation, and chemokine modulation, making it a therapeutic target in cancer and immune disorders.
- Other names
- Dipeptidyl peptidase IVDPPIVgp120Ta1
02
Mechanism of action
Inhibition of DPPIV enzymatic activity; Co-stimulation of T-cells; Antibody-mediated cytotoxicity
03
Biological functions
Enzymatic activityImmune modulationT-cell activationChemokine modulationSignal transduction
04
Disease associations
CancerInflammationImmune disorders
05
Safety considerations
Potential for immune-related adverse eventsOff-target effects due to widespread expression
06
Interacting drugs
YS110
5 more in the full profile.
07
Biomarkers
CD26 expression levels in T-cellsSoluble CD26 levels
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