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Target intelligence / Profile preview
CD27 antigen (CD27)
- Target
- CD27
- Molecular classification
- Type I transmembrane glycoprotein, Tumor necrosis factor receptor superfamily, Receptor
01
Overview
CD27 antigen is a type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily (TNFRSF7). It functions as a costimulatory immune-checkpoint receptor, primarily expressed on T cells, natural killer (NK) cells, and B cells. CD27 plays an essential role in regulating immune responses, particularly in T cell activation, survival, and memory formation. Its ligand is CD70. CD27 is under investigation as an immunotherapy target and soluble forms may serve as biomarkers.
- Other names
- TNFRSF7
02
Mechanism of action
CD27 co-stimulation; Checkpoint regulation modulation
03
Biological functions
Immune responseT cell activationT cell survivalT cell memory formationB cell activationImmunoglobulin synthesisApoptosisCytokine productionCell proliferation
04
Disease associations
CancerViral infectionsAutoimmune conditionsInflammation
05
Safety considerations
Pathological autoimmunityInflammation
06
Biomarkers
Soluble CD27
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