CD27 antisense RNA 1 (CD27-AS1)

CD27 antisense RNA 1 is a long non-coding RNA located on chromosome 12p13.31, transcribed antisense to the CD27 gene (a key T-cell co-stimulatory receptor). It is primarily localized in the nucleus and acts as a regulator of gene expression in cancer cells. Mechanistically, CD27-AS1 serves as a ceRNA by sponging microRNAs (such as miR-224-5p in AML), thereby upregulating oncogenic factors like PBX3, promoting cell proliferation, and inhibiting apoptosis. In melanoma, the CD27-AS1-208 isoform facilitates tumor growth and invasiveness by enhancing STAT3 phosphorylation and JAK-STAT signaling. High levels of CD27-AS1 are associated with poor prognosis and aggressive disease in AML, melanoma, and potentially other cancers, making it a candidate for therapeutic targeting and biomarker development.

Other names

CD27-AS1CD27 antisense RNA 1 (non-protein coding)CD27-AS1-208

Drugs indirectly interacting with CD27-AS1, such as STAT3 inhibitors, would dampen STAT3 activity, potentially suppressing the proliferative effect mediated by CD27-AS1-208 in melanoma. In AML, lncRNA-targeted therapeutic strategies (e.g., antisense oligonucleotides, RNAi, CRISPR) could be designed to inhibit CD27-AS1 and its oncogenic ceRNA effects.