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CD27 Ligand (None)
- Target
- None
- Molecular classification
- Type II transmembrane glycoprotein, Tumor Necrosis Factor Superfamily Ligand
01
Overview
CD27L (CD70) is a type II transmembrane glycoprotein belonging to the TNF ligand superfamily. It is the ligand for CD27 and plays a crucial role in T cell co-stimulation, B cell activation, and NK cell activation. CD70 expression is typically upregulated upon activation of immune cells and its interaction with CD27 is critical for adaptive immune responses. The CD27/CD70 axis is a target for cancer immunotherapy and interventions aimed at modulating immune responses in autoimmune disorders and transplant rejection.
- Other names
- CD70TNFSF7Ki-24 antigenSurface antigen CD70Tumor necrosis factor ligand superfamily member 7Tumor necrosis factor ligand 8A
02
Mechanism of action
CD70 binds to CD27, providing a co-stimulatory signal that promotes T cell activation, proliferation, and differentiation.
03
Biological functions
T cell co-stimulationB cell activationNK cell activationImmune responseCell proliferationEffector/memory differentiation
04
Disease associations
CancerAutoimmunityTransplant rejectionChronic inflammation
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