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Target intelligence / Profile preview
CD27 molecule (CD27)
- Target
- CD27
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily, Type I transmembrane glycoprotein
01
Overview
CD27 is a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF7). It plays a critical role in immune regulation, particularly in T cell activation and survival. It is a type I transmembrane glycoprotein that exists as homodimers. CD27 is primarily expressed on Naïve and activated effector T cells, Natural killer (NK) cells, and Activated B cells. Binding to its ligand, CD70, triggers costimulatory signaling essential for antigen-specific T-cell activation. The CD27/CD70 pathway is implicated in several cancers and soluble CD27 levels are used as biomarkers for immune activity. Anti-CD27 drugs are being evaluated in clinical trials for cancer immunotherapy.
- Other names
- TNFRSF7Tumor necrosis factor receptor superfamily member 7
02
Mechanism of action
Enhances antitumor responses by activating or blocking CD27 signaling.
03
Biological functions
Costimulatory signal for lymphocyte activation/survivalT-cell immunity generation and maintenanceB-cell activation and antibody production regulationNK cell activity modulationNegative feedback control during hematopoiesisRegulation of Th2 lymphocyte function
04
Disease associations
CancerMultiple sclerosisImmune dysregulation
05
Safety considerations
Potential for immune-related adverse events in immunotherapy
06
Interacting drugs
Anti-CD27 drugs
07
Biomarkers
Soluble CD27 (sCD27)
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