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Target intelligence / Profile preview
CD276 antigen (B7-H3)
- Target
- B7-H3
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily, B7 family ligand, Immune checkpoint molecule
01
Overview
CD276 antigen, also known as B7-H3, is a member of the B7 immunoregulatory family and functions as an immune checkpoint molecule with both costimulatory and coinhibitory roles in the immune system. It is a type I transmembrane glycoprotein with two pairs of immunoglobulin-like domains in humans. While mRNA is ubiquitously expressed, protein expression is upregulated in various solid tumors. It regulates T-cell-mediated immune responses and is considered a promising target for cancer immunotherapy.
- Other names
- B7 homolog 34Ig-B7-H3 protein
02
Mechanism of action
Monoclonal antibody, antibody-drug conjugate, bispecific antibody, radioimmunotherapy, nanobody-based CAR-T therapy.
03
Biological functions
Immune response regulationT-cell costimulationT-cell coinhibitionTumor antigen-specific response inhibitionMigrationInvasionAngiogenesisChemoresistanceEpithelial-to-mesenchymal transition (EMT)Tumor metabolism alteration
04
Disease associations
CancerImmune evasion
05
Safety considerations
Potential for immune-related adverse eventsOn-target, off-tumor toxicity
06
Interacting drugs
Enoblituzumab/MGA271
3 more in the full profile.
07
Biomarkers
CD276/B7-H3 expression levels in tumor tissue
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