Target intelligence / Profile preview

CD276 molecule (B7-H3)

Target: B7-H3
Molecular classification: Type I transmembrane protein, Immunoglobulin superfamily, B7 family protein

Overview

CD276 (B7-H3) is a transmembrane glycoprotein belonging to the B7 family of immune proteins and the immunoglobulin superfamily. It functions as an immune checkpoint molecule with dual immunoregulatory roles, acting as both a costimulatory and coinhibitory signal for T cells. B7-H3 is highly overexpressed in a wide range of human solid cancers, making it an attractive target for cancer immunotherapy. Therapeutic approaches include monoclonal antibodies and antibody-drug conjugates (ADCs) that target B7-H3 expressing tumor cells.

Other names: B7 Homolog 3B7-H34Ig-B7-H3B7-H3 VCVC2Ig-B7-H3B7-H3 VC

Mechanism of action

Monoclonal antibodies: Antibody-dependent cell-mediated cytotoxicity (ADCC), direct inhibition of B7-H3 function. Antibody-drug conjugates: Delivery of cytotoxic payload to B7-H3 expressing cells.

Biological functions

Immune checkpoint regulationT cell costimulation (context-dependent)T cell coinhibition (context-dependent)

Disease associations

Cancer

Safety considerations

Potential for off-target effects due to B7-H3 expression in some normal tissuesImmune-related adverse events

Interacting drugs

Monoclonal antibodies against B7-H3

1 more in the full profile.

Biomarkers

B7-H3 protein expression level in tumor tissueSoluble B7-H3 (sB7-H3) levels

Beyond the preview

Go deeper on CD276 molecule (B7-H3).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on CD276 molecule (B7-H3).

Explore the full profile