Gosset Molecular Classification
Immunoglobulin superfamily, Receptor
Other Names
Cd3e molecule, IMD18, TiT3 complex epsilon polypeptide, Leu4-epsilon chain, TCRE
Disease Roles
CD3 epsilon chain Overview
The CD3 epsilon chain (CD3E) is a polypeptide component of the T-cell receptor (TCR)-CD3 complex, essential for T-cell development and activation. It forms heterodimers with either CD3 delta or gamma chains and contains an ITAM motif, crucial for signal transduction upon antigen recognition. Mutations in this gene can cause severe combined immunodeficiency and have been linked to autoimmune diseases such as type I diabetes.
Mechanism of Action
Monoclonal antibodies targeting CD3 epsilon are used for immunosuppression by modulating T-cell function.
Biological Functions
Signal transduction
Immune response
T cell activation
T cell development
Disease Associations
Severe combined immunodeficiency
Type I diabetes
Autoimmune diseases
Safety Considerations
- Immunosuppression
- Increased susceptibility to infection