Molecular Classification
Immunoglobulin superfamily, Receptor
Other Names
T-cell surface glycoprotein CD3 epsilon chain, CD3e molecule, epsilon
Disease Roles
ImmunodeficiencyAutoimmune diseasesType I diabetes mellitus

CD3 epsilon subunit of T cell receptor complex Overview

CD3E is an essential component of the T cell receptor (TCR)-CD3 complex. It plays a crucial role in T cell development, activation, and signal transduction following antigen recognition. The CD3E subunit contains an ITAM motif in its cytoplasmic tail, which is critical for initiating intracellular signaling cascades. Mutations or defects in CD3E can lead to severe combined immunodeficiency, and altered expression levels have been associated with autoimmune diseases like type I diabetes.

Mechanism of Action

Biological Functions

Signal transduction
Immune response
T cell development
T cell activation

Disease Associations

Immunodeficiency
Autoimmune diseases
Type I diabetes mellitus

Safety Considerations

  • Immunosuppression
  • Autoimmunity

Associated Biomarkers

Biomarker
T cell populations
CD3E expression levels