Molecular Classification
Receptor, Single-pass type I membrane protein
Other Names
CD3 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, CD3e
Disease Roles
Severe combined immunodeficiencyAutoimmune diseasesImmunodeficiency 18

CD3 epsilon subunit of the T-cell receptor complex Overview

The CD3 epsilon (CD3ε) polypeptide is a critical component of the T-cell receptor (TCR)-CD3 complex, which is essential for antigen recognition and signal transduction in T cells. It is required for proper thymocyte development, and its absence leads to severe immunodeficiency. Mutations or defects in CD3E can cause severe combined immunodeficiency syndromes. Genetic variants have also been linked with increased susceptibility to autoimmune diseases.

Mechanism of Action

N/A

Biological Functions

Signal transduction
T cell activation
T cell development
Immune response
TCR-CD3 complex assembly

Disease Associations

Severe combined immunodeficiency
Autoimmune diseases
Immunodeficiency 18

Safety Considerations

  • Immunodeficiency due to impaired T cell development/function
  • Potential link to autoimmunity