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Target intelligence / Profile preview
CD30 antigen (CD30)
- Target
- CD30
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
CD30 antigen (TNFRSF8) is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. It is expressed on activated lymphocytes and is highly expressed in certain lymphomas, including Hodgkin's lymphoma and anaplastic large cell lymphoma. CD30 plays a role in signal transduction, apoptosis regulation, and immune regulation. It is a therapeutic target for antibody-drug conjugates like brentuximab vedotin.
- Other names
- TNFRSF8Tumor Necrosis Factor Receptor Superfamily Member 8Ki-1 antigen
02
Mechanism of action
Antibody-drug conjugate targeting CD30, leading to cell death upon internalization
03
Biological functions
Signal transductionApoptosis regulationImmune regulationCellular growth regulationCellular transformation regulation
04
Disease associations
Hodgkin's lymphomaAnaplastic large cell lymphomaNon-Hodgkin's lymphomaEmbryonal carcinomaAutoimmunityInflammatory diseases
05
Safety considerations
Side effects associated with brentuximab vedotin, including peripheral neuropathy, neutropenia, and infusion-related reactions
06
Interacting drugs
Brentuximab vedotin
07
Biomarkers
Soluble CD30 (sCD30)
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