CD300 molecule like family member B (CD300LB)

CD300 molecule like family member B (CD300LB or CD300b) is a protein-coding gene belonging to the immunoglobulin superfamily, functioning as a nonclassical activating receptor predominantly expressed on myeloid cells such as monocytes and granulocytes. CD300LB is a type I transmembrane protein characterized by a single extracellular IgV-like domain and a charged transmembrane residue necessary for interaction with adaptor molecules (notably DAP12), leading to immune cell activation. Signaling through CD300LB contributes to innate immune system pathways by modulating responses to pathogens and regulating inflammatory processes; its function is distinct from inhibitory CD300 family members, as it delivers activating signals via ITAM-containing adaptors and the GRB2 signaling pathway. The receptor's expression and activation can shape host immune responses in various disease states—such as infectious diseases, allergies, and cancer—making it a subject of therapeutic interest and a potential diagnostic target in immune-mediated pathologies.

Other names

CD300bCLM-7CLM7CMRF35-A2IREM-3IREM3TREM-5TREM5CMRF35-like molecule 7Triggering receptor expressed on myeloid cells 5Immune receptor expressed on myeloid cells 3CD300 antigen like family member BLeukocyte mono-Ig-like receptor 5

Activates immune effector functions via association with ITAM-bearing adaptors such as DAP12 (TYROBP) and through recruitment of GRB2