CD300 molecule like family member D (CD300LD)

CD300 molecule like family member D (CD300LD) is a member of the CD300 family of immunoglobulin superfamily receptors, typically classified as a type I transmembrane protein found on immune cells[6][1][5]. It is predicted to function as both an activating and inhibitory receptor, participating in the modulation of immune responses and inflammatory signaling[3][5]. In mice, it has been identified as a functional virus receptor for murine norovirus, dictating species tropism[7]. CD300LD is involved in regulation of cytokine production, including interleukin-6 and tumor necrosis factor, and is implicated in a variety of immune system pathways, such as innate immunity and antigen processing[5][6]. Like other CD300 family members, its ability to bind exposed lipids on cell surfaces links it to the recognition of dead or activated immune cells, suggesting a potential role in infection, inflammation, and immune homeostasis[3][5][6]. No approved therapeutic drugs, validated clinical biomarkers, or specific safety concerns for this target in humans have been reported in the available literature.

Other names

CMRF35-like molecule 5CD300LDCD300DCMRF35A4UNQ9218/PRO28686CLM-5CMRF35-A4CLM-4CD300 antigen-like family member Dimmune receptor CD300d