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Target intelligence / Profile preview
CD300a molecule (CD300A)
- Target
- CD300A
- Molecular classification
- Receptor, Type I transmembrane protein, CD300 family
01
Overview
CD300A is a type I transmembrane protein and a member of the CD300 family of cell surface receptors, known for regulating immune cell functions. It acts as an inhibitory receptor through its ITIM motifs, dampening immune responses upon ligand binding (Phosphatidylserine, Phosphatidylethanolamine). It's implicated in autoimmunity, allergies/inflammatory diseases, cancer, and viral infections, making it a potential therapeutic target.
02
Mechanism of action
CD300A engagement inhibits activation signals from various activating receptors, leading to reduced calcium mobilization and cytokine production. It also downregulates uptake/phagocytosis of apoptotic/dead cells by macrophages.
03
Biological functions
Immune responseInhibitory signalingRegulation of cytokine productionModulation of phagocytosis
04
Disease associations
AutoimmunityAllergy/inflammationCancerViral infection
05
Safety considerations
Potential for broad immunosuppression if targeted systemicallyPossible disruption of tissue homeostasis due to altered phagocytosis
06
Biomarkers
Differential expression patterns in certain disease states
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