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Target intelligence / Profile preview
CD320 molecule (CD320)
- Target
- CD320
- Molecular classification
- Receptor, Membrane protein
01
Overview
CD320 molecule (CD320) is a membrane-associated receptor also known as the transcobalamin receptor or TCblR, which mediates the uptake of vitamin B12 into cells by binding transcobalamin saturated with cobalamin (vitamin B12)[5]. It is expressed in a range of human tissues and plays a central physiological role in vitamin B12 homeostasis[4][5]. Dysfunction or altered expression has been implicated in neurological disorders, with the soluble receptor form in cerebrospinal fluid showing association with dementia-related conditions[3][5].
- Other names
- 8D68D6ATCblRCD320 antigenTranscobalamin receptor
02
Mechanism of action
Facilitates cellular uptake of transcobalamin (vitamin B12 carrier protein) saturated with cobalamin (vitamin B12), thereby supporting vitamin B12 delivery into cells
03
Biological functions
Cobalamin (vitamin B12) uptakeVitamin transportCellular uptake of transcobalamin-bound cobalamin
04
Disease associations
Neurological disease (“soluble transcobalamin receptor is present in cerebrospinal fluid and correlates to dementia-related…”)potentially other disorders of cobalamin metabolism
05
Biomarkers
Soluble transcobalamin receptor (CD320) in cerebrospinal fluid proposed as a potential biomarker related to dementia
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