Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD33 molecule (CD33)
- Target
- CD33
- Molecular classification
- Immunoglobulin superfamily, SIGLECs, Other immune checkpoint proteins, Receptor
01
Overview
CD33, also known as Siglec-3, is a transmembrane receptor predominantly expressed on cells of the myeloid lineage. It functions as an inhibitory receptor, modulating immune responses by dampening tyrosine kinase-driven signaling pathways. CD33 is an important marker for AML diagnosis and serves as a therapeutic target. Genetic variants are also associated with Alzheimer's disease risk.
- Other names
- SIGLEC3SIGLEC-3gp67p67
02
Mechanism of action
Inhibition of cellular activation via ITIM phosphorylation and recruitment of SHP1/SHP2
03
Biological functions
Immune responseSignal transductionModulation of immune cell activityInhibition of cellular activation
04
Disease associations
Alzheimer's diseaseAcute myeloid leukemiaCardiovascular system diseaseMyeloid leukemia susceptibility
05
Safety considerations
On-target, off-tumor toxicity due to CD33 expression on normal myeloid cellsPotential for immune-related adverse events
06
Interacting drugs
Antibody-drug conjugates targeting CD33
07
Biomarkers
CD33 expression level in AML blasts
Beyond the preview
Go deeper on CD33 molecule (CD33).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD33 molecule (CD33).