Target intelligence / Profile preview

CD34 antigen (None)

Target: None
Molecular classification: Sialomucin, Single-pass type I transmembrane protein

Overview

CD34 is a single-pass transmembrane phosphoglycoprotein, classified as a sialomucin, highly expressed on early hematopoietic progenitor cells and vascular endothelial cells. It functions as an adhesion molecule in hematopoiesis, facilitates T-cell entry into lymph nodes, and may act as an anti-adhesive molecule. Clinically, it's used as a marker for stem cell identification and tumor angiogenesis assessment.

Mechanism of action

N/A

Biological functions

Cell adhesionCell migrationHematopoiesis regulationMaintenance of progenitor cell stateL-selectin ligand

Disease associations

Cancer (angiogenesis)Hematological malignancies

Biomarkers

Hematopoietic stem/progenitor cell markerAngiogenesis marker in tumors

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