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Target intelligence / Profile preview
CD36 antigen (CD36)
- Target
- CD36
- Molecular classification
- Scavenger receptor, Transporter, Membrane protein, Glycoprotein
01
Overview
CD36 antigen is a heavily glycosylated, integral membrane protein that functions as both a scavenger receptor and a transporter. It is widely expressed on various cell types and binds a diverse array of ligands, including thrombospondins, collagen, oxidized LDL, and fatty acids. CD36 plays a crucial role in lipid metabolism, immunity, angiogenesis, and platelet function. Aberrant expression or function of CD36 is implicated in several diseases, including cardiovascular disease, metabolic syndrome, neurodegenerative conditions, and cancer, making it an attractive therapeutic target.
- Other names
- Platelet glycoprotein IVGPIVGPIIIbFatty acid translocaseFATScavenger receptor class B member 3SCARB3
02
Mechanism of action
Modulation of fatty acid transport, scavenger receptor activity, or angiogenesis pathways.
03
Biological functions
Fatty acid transportScavenger receptor activityPhagocytosisAdhesionAngiogenesis regulationImmune responseLipid metabolism regulationSignal transduction
04
Disease associations
Platelet glycoprotein IV deficiencyCoronary heart diseaseGlucose intoleranceAtherosclerosisHypertensionDiabetes mellitusCardiomyopathyAlzheimer’s diseaseCancerInflammation
05
Safety considerations
Potential for off-target effects due to broad expression profileRisk of disrupting normal lipid metabolismPotential for exacerbating inflammation in certain contextsPossible interference with platelet function
06
Biomarkers
CD36 expression levels in various tissues/cellsSoluble CD36 levelsLipid accumulation in macrophages
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