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Target intelligence / Profile preview
Cluster of Differentiation 38 (CD38)
- Target
- CD38
- Molecular classification
- Glycoprotein, Enzyme, Receptor
01
Overview
Cluster of Differentiation 38 (CD38) is a multifunctional glycoprotein expressed on the surface of various immune cells. It acts as an enzyme catalyzing the metabolism of NAD+ to produce second messengers such as cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), regulating intracellular calcium release. CD38 also functions in cell adhesion and signal transduction. It is a therapeutic target for multiple myeloma and light chain amyloidosis, with implications in autoimmune diseases, inflammation, and age-related metabolic decline.
- Other names
- Cyclic ADP ribose hydrolase
02
Mechanism of action
Monoclonal antibody targeting CD38; inhibition of NADase function
03
Biological functions
Enzymatic conversion of NAD+Cell adhesionSignal transductionImmune cell activationRegulation of intracellular calcium release
04
Disease associations
Multiple myelomaLight chain amyloidosisAutoimmune diseasesInflammationBile acid-induced pancreatitisAge-related metabolic decline
05
Interacting drugs
Daratumumab
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