Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD38 antigen (CD38)
- Target
- CD38
- Molecular classification
- Ectoenzyme, Type II transmembrane glycoprotein, Receptor, Adhesion molecule
01
Overview
CD38 is a 45 kDa type II transmembrane glycoprotein with multiple enzymatic activities, including NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP ribose hydrolase. It is expressed on various immune cells and plays roles in cell adhesion, signal transduction, calcium signaling, and regulation of migration. CD38 is a therapeutic target in multiple myeloma due to its high expression on plasma cells and MM cells, allowing anti-CD38 antibodies to mediate cell death via CDC and ADCC. It also has a role in regulating immune responses and is a marker for immune activation.
02
Mechanism of action
Complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), direct apoptosis induction, and modulation of immune responses.
03
Biological functions
NAD+ glycohydrolase activityADP-ribosyl cyclase activityCyclic ADP ribose hydrolase activityCalcium signalingCell adhesionSignal transductionRegulation of migrationImmune response modulationPhagocytosisAntigen presentationCytokine release regulationB cell receptor complex modulation
04
Disease associations
CancerMultiple MyelomaInflammationInfectionImmune disorders
05
Safety considerations
Infusion-related reactionsImmunosuppressionNeutropeniaThrombocytopeniaSecondary infections
06
Interacting drugs
Anti-CD38 antibodies (e.g., Daratumumab)
07
Biomarkers
CD38 expression level in immune cellsCD38 expression in tumor cells (e.g., multiple myeloma)
Beyond the preview
Go deeper on CD38 antigen (CD38).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD38 antigen (CD38).