CD4+ T-cell receptor specific for Dermatophagoides pteronyssinus allergen 2–MHC class II complex (Der p 2-specific TCR)

The CD4+ T-cell receptor (TCR) specific for Der p 2–MHC class II complexes is a pivotal mediator in the development and persistence of house dust mite (HDM) allergy. Der p 2 is a major 14-kDa allergen from Dermatophagoides pteronyssinus that possesses structural homology to MD-2, allowing it to facilitate TLR4 signaling and promote potent Th2-biased immune responses (PMID: 19633648). When Der p 2 is internalized and processed by antigen-presenting cells, its peptide fragments are displayed on MHC class II molecules for recognition by these specific TCRs. This interaction leads to the activation of CD4+ T cells, which in allergic individuals secrete cytokines such as IL-4, IL-5, and IL-13, driving IgE production and chronic eosinophilic inflammation in the airways (PMID: 30103050). Therapeutic strategies targeting this TCR-MHC interaction, such as allergen-specific immunotherapy (AIT), aim to induce immunological tolerance by promoting the expansion of regulatory T cells (Tregs) and shifting the cytokine profile away from Th2 dominance (PMID: 28213450). The use of MHC II tetramers to track these specific T-cell populations has become a vital tool for monitoring the efficacy of desensitization treatments and understanding the mechanisms of immune deviation.

Other names

Der p 2-specific T-cell receptorHouse dust mite allergen 2-specific TCRMHC class II-restricted Der p 2-reactive TCRCD4+ T-cell receptors specific for Der p 2–MHC class II complexes

Induction of immune tolerance through allergen-specific immunotherapy (AIT), leading to T-cell anergy, deletion, or immune deviation from a Th2-dominated profile to a Th1 or regulatory T-cell (Treg) profile (PMID: 28213450).