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Target intelligence / Profile preview
CD4 Binding Site of HIV Envelope Glycoprotein gp120 (gp120 CD4 Binding Site)
- Target
- gp120 CD4 Binding Site
- Molecular classification
- Receptor, Glycoprotein
01
Overview
The CD4 binding site of HIV envelope glycoprotein gp120 is a critical component in the viral entry process. It binds to the CD4 receptor on host cells, inducing conformational changes that facilitate interaction with coreceptors (CCR5 or CXCR4) and subsequent fusion of viral and host membranes. This site is a major target for vaccine development and therapeutic intervention, as it is exposed and accessible to antibodies and inhibitors[1][2][3].
- Other names
- HIV-1 gp120 CD4 Binding DomainHIV Envelope Glycoprotein CD4 Binding Site
02
Mechanism of action
Inhibiting viral entry by blocking CD4 binding or subsequent steps in the fusion process
03
Biological functions
Virus EntryImmune ResponseCell Membrane Fusion
04
Disease associations
HIV InfectionImmunodeficiency
05
Safety considerations
Potential for inducing immune responses against self CD4 moleculesdrug resistance
06
Interacting drugs
Maraviroc (blocks coreceptor interaction after CD4 binding)
2 more in the full profile.
07
Biomarkers
CD4 T cell countViral load
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