CD4-positive T cell receptor via PADRE epitope (TCR/CD4-PADRE)

The "CD4-positive T cell receptor via PADRE epitope" refers to the molecular complex formed when a CD4+ T cell recognizes an antigenic peptide (PADRE) presented by MHC class II molecules on antigen-presenting cells (APCs). This recognition is mediated by the T cell receptor (TCR) in conjunction with the CD4 co-receptor, leading to T cell activation and subsequent immune responses. PADRE is a synthetic universal T helper epitope designed to bind broadly across human HLA-DR alleles, ensuring robust activation of CD4+ T cells regardless of individual HLA type. It is used extensively in immunotherapy research to activate helper responses across populations.

Other names

CD4+ T cell receptor complex with PADREPADRE-MHCII-TCR-CD4 complexTCR activation via PADREHelper T cell receptor signaling

TCR/CD4 complex binds to PADRE-MHCII, triggering intracellular signaling cascades via Lck kinase phosphorylation, leading to T cell activation, cytokine production, and proliferation.