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Target intelligence / Profile preview
CD40 Costimulatory Receptor (CD40)
- Target
- CD40
- Molecular classification
- Type I transmembrane glycoprotein, Tumor Necrosis Factor Receptor Superfamily
01
Overview
CD40 is a costimulatory receptor that plays a central role in immune regulation and homeostasis. It is a 48-kDa type I transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. The engagement between CD40 and its ligand (CD154/CD40L) triggers bidirectional signaling critical for both humoral and cellular immunity. Targeting the CD40–CD154 axis has therapeutic potential for cancer immunotherapy or modulation of autoimmune conditions.
02
Mechanism of action
Targeting the CD40–CD154 axis has therapeutic potential for cancer immunotherapy or modulation of autoimmune conditions
03
Biological functions
Costimulation for humoral/cellular immunityB cell activation, proliferation, survivalImmunoglobulin class switchingGerminal center formationMemory B cell maturationDendritic cell survival/maturationUpregulation of costimulatory moleculesT-cell primingMacrophage activationCytokine production
04
Disease associations
AutoimmunityInflammatory diseasesCancerImmune deficiency
05
Safety considerations
Overactivation or dysregulation implicated in autoimmunity/inflammatory diseases/cancerDeficiency or dysfunction leads to impaired antibody responses/class switching/germinal center formation
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