Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 5 (TNFSF5)
- Target
- TNFSF5
- Molecular classification
- Cytokine, Ligand, Tumor Necrosis Factor Ligand Superfamily
01
Overview
Tumor necrosis factor ligand superfamily member 5 (TNFSF5), also known as CD40 ligand (CD40L) or CD154, is a key cytokine in the tumor necrosis factor (TNF) superfamily. It plays a central role in immune regulation, particularly in the activation and differentiation of B cells, and is essential for effective immune responses. CD40L binds to its receptor, CD40, on B cells and other antigen-presenting cells, triggering signaling pathways that regulate B cell proliferation, immunoglobulin class switching, and other immune functions. Disruption of the CD40-CD40L pathway impairs humoral immunity and can lead to Hyper-IgM syndrome. Targeting this pathway has been explored for autoimmune diseases.
- Other names
- CD40 ligandCD40LCD154BP50P50CDw40B-cell surface antigen CD40CD154 receptor
02
Mechanism of action
Modulation of CD40 signaling
03
Biological functions
Immune responseB cell proliferationImmunoglobulin class switchingGerminal center formationMemory B cell developmentInflammationHost defenseCell growth regulationCell survival regulationCell differentiation regulationApoptosis regulationSignal transduction
04
Disease associations
Autoimmune diseasesHyper-IgM syndromeInflammationInfection
05
Safety considerations
Potential for immunosuppressionRisk of infection
Beyond the preview
Go deeper on Tumor Necrosis Factor Ligand Superfamily Member 5 (TNFSF5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor Necrosis Factor Ligand Superfamily Member 5 (TNFSF5).