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Target intelligence / Profile preview
Cluster of Differentiation 40 Receptor (CD40)
- Target
- CD40
- Molecular classification
- Receptor, Type I transmembrane glycoprotein, Tumor Necrosis Factor Receptor Superfamily
01
Overview
CD40, also known as Cluster of Differentiation 40, is a type I transmembrane protein and a member of the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells (DCs), macrophages, and monocytes. CD40 is essential for activation of APCs; binding by its ligand CD154 leads to upregulation of costimulatory molecules necessary for effective T-cell priming and differentiation. The central role played by the CD40/CD154 axis makes it a key target for modulating immune responses, and has been implicated in diseases ranging from cancer immunotherapy settings to neurodegenerative disorders like Alzheimer’s disease.
- Other names
- CD40 receptorCD40TNFRSF5
02
Mechanism of action
Agonistic anti-CD40 antibodies enhance antitumor immunity by activating APCs. Blockade strategies dampen pathological inflammation or autoimmunity.
03
Biological functions
Immune cell activationAntigen presentationB-cell activationT-cell primingCytokine productionInflammatory responseIg class switch recombinationMemory/plasma cell generationSignal transduction
04
Disease associations
ImmunodeficiencyHyper-IgM syndromeCancerInflammationAutoimmunityAlzheimer's disease
05
Safety considerations
Potential for cytokine stormExacerbation of autoimmune conditions
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