Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD44 antigen (CD44)
- Target
- CD44
- Molecular classification
- Cell surface glycoprotein, Transmembrane receptor
01
Overview
CD44 antigen is a highly versatile transmembrane glycoprotein involved broadly in immune function, tissue homeostasis/regeneration processes—including roles critical for cancer biology—through its diverse isoforms generated by alternative splicing.
- Other names
- HCAMhoming cell adhesion moleculePgp-1phagocytic glycoprotein-1Hermes antigenlymphocyte homing receptorECMR-IIIHUTCH-1
02
Mechanism of action
Monoclonal antibodies targeting specific CD44 variants
03
Biological functions
Lymphocyte activation/recirculation/homingHematopoiesisTumor metastasisInflammationResponse to infectionCell-matrix adhesionSignal transductionApoptosis regulationCytoskeletal reorganization
04
Disease associations
CancerLichen sclerosusPleural mesotheliomaEndometriosisHead/neck squamous carcinomaInflammationInfection
05
Safety considerations
Context-dependent effects in cancer (prognosis/survival)Potential for off-target effects due to widespread expression
06
Interacting drugs
Bivatuzumab
07
Biomarkers
Effector-memory T-cells markerCancer stem cell marker (CD44+/CD24-)
Beyond the preview
Go deeper on CD44 antigen (CD44).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD44 antigen (CD44).