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Target intelligence / Profile preview
CD44 antigen (CD44)
- Target
- CD44
- Molecular classification
- Cell surface glycoprotein, Transmembrane receptor
01
Overview
CD44 antigen is a highly versatile transmembrane glycoprotein involved broadly in immune function, tissue homeostasis/regeneration processes—including roles critical for cancer biology—through its diverse isoforms generated by alternative splicing.
- Other names
- HCAMhoming cell adhesion moleculePgp-1phagocytic glycoprotein-1Hermes antigenlymphocyte homing receptorECMR-IIIHUTCH-1
02
Mechanism of action
Monoclonal antibodies targeting specific CD44 variants
03
Biological functions
Lymphocyte activation/recirculation/homingHematopoiesisTumor metastasisInflammationResponse to infectionCell-matrix adhesionSignal transductionApoptosis regulationCytoskeletal reorganization
04
Disease associations
CancerLichen sclerosusPleural mesotheliomaEndometriosisHead/neck squamous carcinomaInflammationInfection
05
Safety considerations
Context-dependent effects in cancer (prognosis/survival)Potential for off-target effects due to widespread expression
06
Interacting drugs
Bivatuzumab
07
Biomarkers
Effector-memory T-cells markerCancer stem cell marker (CD44+/CD24-)
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