Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD44 Variant 6 (CD44v6)
- Target
- CD44v6
- Molecular classification
- Transmembrane glycoprotein, Receptor
01
Overview
CD44 variant 6 (CD44v6) is a specific isoform of the CD44 cell surface glycoprotein, generated through alternative splicing that includes exon v6. It plays key roles in cell-cell and cell-matrix interactions, adhesion, migration, proliferation, and signaling. Overexpression of CD44v6 is observed in several malignancies, associated with increased invasiveness and metastatic potential. It acts as a co-receptor for receptor tyrosine kinases such as MET, promoting signaling pathways like Ras-MAPK and PI3K/Akt. CD44v6 is a prognostic marker in several cancers and a therapeutic target with monoclonal antibodies and antibody-drug conjugates under development.
02
Mechanism of action
Targeted inhibition of CD44v6-mediated cell adhesion, migration, and signaling pathways.
03
Biological functions
Cell adhesionCell migrationSignal transductionCo-receptor activity
04
Disease associations
CancerMetastasis
05
Safety considerations
Potential off-target effects due to CD44 expression in normal tissuesImmunogenicity of antibody-based therapies
06
Interacting drugs
Monoclonal antibodies targeting CD44v6
1 more in the full profile.
07
Biomarkers
CD44v6 expression levelLymph node metastasis (LNM)Peritoneal disseminationAdvanced disease stage
Beyond the preview
Go deeper on CD44 Variant 6 (CD44v6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD44 Variant 6 (CD44v6).