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CD44 Variant 9 Antigen (None)
- Target
- None
- Molecular classification
- Adhesion molecule, Transmembrane glycoprotein
01
Overview
CD44 variant 9 antigen (CD44v9) is a specific isoform of the CD44 transmembrane glycoprotein, generated by alternative splicing. It plays a critical role in tumor initiation, maintenance, and metastasis, and contributes to chemoresistance by enhancing the antioxidant capacity of cancer cells through interaction with the xCT transporter and subsequent glutathione synthesis. It is a promising target for cancer diagnosis and therapy, with monoclonal antibodies being developed to specifically target the v9 region.
- Other names
- CD44v9CD44 isoform 9CD44 variant 9
02
Mechanism of action
Monoclonal antibodies (e.g., C_44Mab‐1) target the v9 region
03
Biological functions
Cell adhesionCell migrationCell invasionCell survivalTumor initiationTumor maintenanceMetastasisROS defense
04
Disease associations
CancerChemoresistance
05
Safety considerations
Potential for off-target effects if targeting CD44v9 in normal tissues expressing low levelsDevelopment of resistance mechanisms
06
Biomarkers
Hepatocellular carcinoma (HCC)Colorectal cancerEarly gastric cancersOral squamous cell carcinomaLung adenocarcinomaEGFR-mutant tumors
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