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Target intelligence / Profile preview
CD44 Variant Domain 6 (CD44v6)
- Target
- CD44v6
- Molecular classification
- Transmembrane glycoprotein, Cell surface receptor, Adhesion molecule
01
Overview
CD44 variant domain 6 (CD44v6) is a specific isoform of the CD44 glycoprotein resulting from alternative splicing of the CD44 gene. It plays a significant role in cell adhesion, migration, signal transduction, and matrix assembly. CD44v6 is implicated in cancer progression, metastasis, and is explored as a therapeutic target due to its overexpression in various solid tumors and its involvement in cancer initiating cell activities. It is a target for antibody-based therapies and targeted nanocarriers.
- Other names
- CD44v6 isoformCD44 variant 6CD44 splice variant 6
02
Mechanism of action
Antibody-mediated blockage of metastatic spread; targeted delivery of therapeutic agents via nanocarriers.
03
Biological functions
Cell adhesionCell migrationSignal transductionMatrix assemblyCytokine/chemokine harboringExosome biogenesisHyaluronan binding
04
Disease associations
CancerMetastasisTumor progressionCancer initiating cells (CIC)
05
Safety considerations
Potential for off-target effects in normal tissues expressing low levels of CD44v6Development of resistance to CD44v6-targeted therapiesImmunogenicity of antibody-based therapies
06
Biomarkers
Depth of tumor invasionPresence of metastatic tumor cellsPSA-free survival (prostate cancer)Expression levels in tumor tissue
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