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Target intelligence / Profile preview
CD44 variant isoform 6 (CD44v6)
- Target
- CD44v6
- Molecular classification
- Type I transmembrane glycoprotein, Cell adhesion molecule, Receptor
01
Overview
CD44 variant isoform 6 (CD44v6) is a specific splice variant of the CD44 family of transmembrane glycoproteins. It plays a critical role in cell-cell interactions, adhesion, and migration. CD44v6 is upregulated in various cancers, contributing to tumor progression, metastasis, and chemoresistance. It acts as a co-receptor and signaling hub, influencing survival pathways.
- Other names
- CD44 splice variant 6CD44v6-containing isoforms
02
Mechanism of action
Not applicable (target for therapeutics, not a drug itself)
03
Biological functions
Cell adhesionCell migrationSignal transductionCo-receptor activityApoptosis regulationAutophagy regulationEpithelial-mesenchymal transition (EMT)
04
Disease associations
CancerInflammationMetastasis
05
Safety considerations
Upregulation in cancer can promote tumor progression and metastasisPotential involvement in chemoresistance
06
Biomarkers
Lymph node metastasis (LNM) in invasive breast carcinomaTumor progression/metastasis risk assessment (various cancers)
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