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Target intelligence / Profile preview
CD44 variant isoform v6 (CD44v6)
- Target
- CD44v6
- Molecular classification
- Cell surface glycoprotein, Receptor, Adhesion molecule
01
Overview
CD44 variant isoform v6 (CD44v6) is a specific splice variant of the CD44 cell surface glycoprotein, arising from alternative splicing of the CD44 gene. It functions as a co-receptor for receptor tyrosine kinases, particularly c-Met/HGF, and modulates apoptosis and chemoresistance. CD44v6 plays a role in cell adhesion, migration, and is implicated in tumor progression and metastasis. Its expression levels correlate with more aggressive phenotypes in several cancers and serve as a marker for disease progression. Targeting CD44v6 holds therapeutic potential due to its restricted expression and central role in cancer cell survival.
- Other names
- CD44v6 isoformCD44 variant 6
02
Mechanism of action
Blocking CD44v6 interaction with ligands; inhibiting downstream signaling pathways
03
Biological functions
Cell adhesionCell migrationLymphocyte homingSignal transductionApoptosis regulationChemoresistanceAutophagy
04
Disease associations
CancerMetastasisInflammation
05
Safety considerations
Potential for off-target effects due to CD44 expression in normal tissuesDevelopment of resistance mechanisms
06
Biomarkers
CD44v6 expression level in tumor tissue
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