Target intelligence / Profile preview

CD46 Molecule (CD46)

Target: CD46
Molecular classification: Type I transmembrane protein, Complement regulatory protein, Receptor

Overview

CD46, also known as Membrane Cofactor Protein (MCP), is a type I transmembrane glycoprotein that regulates the complement system and serves as a receptor for several pathogens. It is expressed on all nucleated human cells and plays a crucial role in protecting cells from autologous complement attack and modulating immune responses. Dysregulation of CD46 is implicated in diseases such as atypical hemolytic uremic syndrome and cancer metastasis.

Other names: Membrane Cofactor ProteinMCPCluster of Differentiation 46

Mechanism of action

Acts as a cofactor for complement factor I-mediated cleavage/inactivation of C3b and C4b; serves as a receptor for pathogens.

Biological functions

Complement regulationImmune modulationCofactor for factor I-mediated cleavagePathogen receptorFertilization

Disease associations

Atypical hemolytic uremic syndromeCancer metastasisInfection

Safety considerations

Pathogen exploitation for cell entryPotential for immune dysregulation

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