CD47 molecule pseudogene

The CD47 molecule pseudogene (ENSG00000254890) is a region of DNA that closely resembles the functional CD47 gene but contains mutations or disruptions that prevent it from producing a functional protein. Pseudogenes like this arise throughout evolution via gene duplication, retrotransposition, or gene disabling mutations[3][7]. While the parent CD47 gene encodes a widely-expressed membrane receptor involved in immune modulation (notably as a target for cancer immunotherapy), the pseudogene is not expressed as a functional protein and holds no direct therapeutic, diagnostic, or mechanistic relevance[1][6]. Scientifically, pseudogenes may serve as evolutionary markers or occasionally exert regulatory RNA effects, but no such role is established for the CD47 molecule pseudogene[3][5]. Key distinctions: - The CD47 gene/protein (not the pseudogene) is a validated therapeutic target in oncology and immunology[2][4][6]. - The CD47 molecule pseudogene does *not* encode an active protein, receptor, or therapeutic target, making it unsuitable for drug development or biomarker use[1][3][7].

Other names

CD47 pseudogeneENSG00000254890