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Target intelligence / Profile preview
CD5 protein (CD5)
- Target
- CD5
- Molecular classification
- Transmembrane glycoprotein, Scavenger receptor superfamily
01
Overview
CD5 is a transmembrane glycoprotein and a member of the scavenger receptor superfamily. It is predominantly expressed on T cells and a subset of B cells and functions as a key regulator of immune responses. CD5 primarily acts by modulating signaling through the T cell receptor (TCR) and B cell receptor (BCR), generally inhibiting their activation. It's involved in thymocyte selection, peripheral tolerance, and differentiation of T helper cell subsets. As such, it represents a potential therapeutic target for immune-related diseases.
- Other names
- Leu-1Ly-1T1
02
Mechanism of action
Modulation of T cell receptor (TCR) and B cell receptor (BCR) signaling pathways, primarily through negative regulation.
03
Biological functions
Immune regulationNegative regulation of antigen receptor signalingTCR signaling modulationBCR signaling modulationThymocyte developmentPeripheral survivalToleranceTh17 differentiationRegulatory T-cell generation
04
Disease associations
AutoimmunityCancerImmune dysregulation
05
Safety considerations
Potential for immunosuppression if targeted too broadlyPotential for autoimmunity if negative regulatory function is disrupted
06
Biomarkers
Expression levels in T cellsExpression levels in B cells
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