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Target intelligence / Profile preview
CD55 antigen (DAF)
- Target
- DAF
- Molecular classification
- GPI-anchored membrane protein
01
Overview
CD55 antigen, also known as Decay-Accelerating Factor (DAF), is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a critical role in regulating the complement system on cell surfaces. It inhibits the formation of C4b2a and C3bBb convertases, thereby preventing the assembly of membrane attack complexes and protecting host cells from complement-mediated lysis. It is widely expressed on blood cells and various tissues and is implicated in tumor biology and pathogen interactions.
- Other names
- Decay-Accelerating FactorComplement decay-accelerating factor
02
Mechanism of action
N/A
03
Biological functions
Regulation of complement systemInhibition of C4b2a convertase formationInhibition of C3bBb convertase formationProtection of autologous cells from complement-mediated lysisImmune modulation
04
Disease associations
CancerInfectionInflammationAutoimmune diseases (implicated, but not directly stated)
05
Safety considerations
Overexpression in tumors promotes angiogenesis, tumorigenesis, invasiveness, and immune evasion.
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