Target intelligence / Profile preview

CD59 molecule (CD59)

Target: CD59
Molecular classification: Glycoprotein, LY6/uPAR/alpha-neurotoxin protein family

Overview

CD59, also known as Membrane Inhibitor of Reactive Lysis (MIRL), MAC-inhibitory protein (MAC-IP), or protectin, is a glycoprotein that inhibits the formation of the complement membrane attack complex (MAC), protecting cells from complement-mediated lysis. It is implicated in diseases such as Paroxysmal Nocturnal Hemoglobinuria (PNH) and is explored as an immunotherapeutic target in cancer.

Other names: Membrane inhibitor of reactive lysisProtectinMAC-inhibitory protein / MAC-IPHRF20P18MIC11

Mechanism of action

Binds to complement components C8 and/or C9, preventing C9 polymerization and MAC formation.

Biological functions

Complement regulationInhibition of membrane attack complex (MAC) formationT-cell activation (signal transduction)Cellular homeostasis

Disease associations

Paroxysmal Nocturnal Hemoglobinuria (PNH)CancerViral Evasion

Beyond the preview

Go deeper on CD59 molecule (CD59).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on CD59 molecule (CD59).

Explore the full profile