CD63 antigen (CD63)

CD63 antigen (CD63) is a member of the tetraspanin family (transmembrane 4 superfamily), characterized by four transmembrane domains and primarily associated with intracellular vesicle membranes, though it can be expressed on the cell surface under certain activation states[1][2]. CD63 interacts with integrins and other membrane proteins, mediating signal transduction events that influence cell development, activation, motility, adhesion, and vesicular transport[1][2]. It is a key marker for activated basophils in allergy diagnostics (basophil activation test), is involved in intracellular trafficking in melanocytes, and has roles as a marker and modulator in cancer (especially melanoma)[1][3]. Deficiency in CD63 is associated with Hermansky-Pudlak syndrome. CD63 is widely used as a lineage, activation, and exosome marker in cell biology and clinical research[1][2].

Other names

CD63 moleculeMLA1TSPAN30LAMP-3Limp1Tspan-30ME491HOP-26Pltgp40AD1GranulophysinLysosomal-associated membrane protein 3Lysosome integral membrane protein 1Melanoma-associated antigen ME491OMA81HOcular melanoma-associated antigenTetraspanin-30AD1 antigengranulophysinlimp1melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspanin-30tspan-30

Antibodies: Mark or block CD63 as a cellular activation and lineage marker (e.g., in allergy diagnostics, flow cytometry). Experimental: Potential modulation of integrin and tetraspanin-related signaling pathways via therapeutic antibodies or ligands.