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Target intelligence / Profile preview
CD70 antigen (None)
- Target
- None
- Molecular classification
- Type II transmembrane protein, Receptor ligand
01
Overview
CD70 antigen is a type II transmembrane protein that acts as a costimulatory ligand for the CD27 receptor, primarily expressed on activated immune cells. It plays a crucial role in T-cell and B-cell activation and proliferation. Overexpression of CD70 is observed in various cancers, making it a promising target for immunotherapeutic interventions such as anti-CD70 antibodies and CAR-T cell therapies.
02
Mechanism of action
Anti-CD70 antibodies bind to CD70, blocking its interaction with CD27 and potentially inducing antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). CAR-T cells expressing anti-CD70 chimeric antigen receptors target and kill CD70-expressing cells.
03
Biological functions
Immune responseT-cell activationB-cell activationCell proliferationCostimulation
04
Disease associations
CancerLymphomaRenal cell carcinomaAutoimmune disorders (potential)
05
Safety considerations
On-target, off-tumor toxicity due to CD70 expression on activated immune cellsCytokine release syndrome (CRS) with CAR-T cell therapyNeurotoxicity with CAR-T cell therapyPotential for immunosuppression
06
Interacting drugs
Anti-CD70 antibodies
1 more in the full profile.
07
Biomarkers
CD70 expression levels in tumor tissueCD70 expression levels on immune cells
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