Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
CD70 molecule (None)
- Target
- None
- Molecular classification
- TNF superfamily, Type II transmembrane protein
01
Overview
CD70, a member of the TNF superfamily, is a costimulatory molecule that interacts with CD27 to regulate immune responses. It is transiently expressed on activated immune cells and overexpressed in various cancers, promoting tumor proliferation and survival. As such, CD70 is an attractive target for immunotherapy, including monoclonal antibodies and CAR-T cell therapies. However, T cell-derived CD70 may also act as an immune checkpoint molecule, potentially limiting inflammatory responses.
02
Mechanism of action
Monoclonal antibodies: Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC); CAR-T cells: T-cell mediated cytotoxicity
03
Biological functions
CostimulationImmune regulationT-cell activationB-cell activationCell proliferationApoptosis
04
Disease associations
CancerImmunodeficiencyAutoimmunity
05
Safety considerations
Immune-related adverse events (irAEs)Cytokine release syndrome (CRS)On-target, off-tumor toxicity
06
Interacting drugs
Monoclonal antibodies against CD70
07
Biomarkers
CD70 expression level in tumor tissueCD70 expression level in immune cells
Beyond the preview
Go deeper on CD70 molecule (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on CD70 molecule (None).